Sure, but reaching those readers is all about the marketing. You can't expect them to hunt for rare needles in overwhelmingly large, wet haystacks. They'll settle. Or they'll do something else. Good writing and good art are rarely commercially viable in a creator's lifetime, because there's always more. Once we die, marketers can take advantage of the shortage.
I was lucky to work as a writer and to be able to retire. Most of my writing, these days, earns a pittance - if that. I'm trying to discipline myself to submit it for publication, though I realize that's old-fashioned. The "stigma" around self-publishing was created by the gatekeepers and perpetuated by bad writing and vanity press. But now, with even the traditional publishers going to "subsidy" route and providing almost no marketing or publicity, for all the difference it really makes, writers might just as well self-publish and cut out the middle-man altogether.